| Children |
| | 1. Sally Tarleton Hughes, b. Abt 1643, King and Queen, Virginia, United States  |
| | 2. Sally Tarleton Hughes, b. Abt 1655, King and Queen, Virginia, United States  |
| | 3. Robert Hughes, b. 1683, Henrico, Virginia, United States , d. 13 Jul 1750, Cumberland, Virginia, United States (Age 67 years) |
| | 4. Elizabeth Hughes, b. 1689 |
| | 5. Mary Hughes, b. Abt 1690, Curles Neck, Henrico, Virginia, USA , d. 9 Dec 1755, Goochland, Virginia, United States (Age ~ 65 years) |
| | 6. Isaac Hughes, b. 1692, Goochland, Virginia, United States , bur. 1758, Cumberland, Virginia, United States (Age ~ 66 years) |
| | 7. Ashford Hughes, b. Abt 1699, Virginia, United States , d. Abt 1749, Goochland, Virginia, United States (Age ~ 50 years) |
| + | 8. Mary Tarleton Hughes, b. 1700, Henrico, Virginia, United States , d. 1755, Albemarle County, Virginia, USA (Age 55 years) |
| | 9. Mary Tarleton Hughes, b. Abt 1700, Henrico, Virginia, United States , d. 1755, Albemarle County, Virginia, USA (Age ~ 55 years) |
| | 10. Martha Hughes, b. Abt 1700, Henrico, Virginia, United States  |
| | 11. Robert Hughes, b. 1704, Cumberland, Virginia, United States , d. 13 Jul 1750, Cumberland, Virginia, United States (Age 46 years) |
| | 12. Jesse Hughes, b. Abt 1707, Virginia, United States  |
| | 13. Isaac Hughes, b. 1690/1720, Goochland, Virginia, United States , d. 1758, Cumberland, Virginia, United States (Age 38 years) |
| | 14. Sarah Hughes, b. Abt 1758, Goochland, Virginia, United States , d. 1755–1817 (Age ~ 59 years) |
|